Advances in Synaptic Plasticity


Many neurons exhibit plasticity; that is, they can change structurally or functionally, often in a lasting way. Plasticity is evident in such diverse phenomena as learning and memory, brain development, drug tolerance, sprouting of axon terminals after a brain lesion, and various cellular forms of activity-dependent synaptic plasticity such as long-term potentiation and long-term depression. This book, a follow-up to the editors' Synaptic Plasticity (MIT Press, 1993), reports on the most recent trends in the field. The levels of analysis range from molecular to cellular and network, the unifying theme being the nature of the relationships between synaptic plasticity and information processing and storage.

Contributors: Yael Amitai, Michel Baudry, Theodore W. Berger, Pierre-Alain Buchs, A.K. Butler, Franck A. Chaillan, Gilbert A. Chauvet, Marie-Françoise Chesselet, Barry W. Connors, Taraneh Ghaffari, Jay R. Gibson, Ziv Gil, Michel Khrestchatisky, Dietmar Kuhl, Carole E. Landisman, Gilles Laurent, Jim-Shih Liaw, David J. Linden, Katrina MacLeod, Henry Markram, W.V. Morehouse, Dominique Muller, J.A. Napieralski, Santiago Rivera, François S. Roman, Bernard Soumireu-Mourat, Oswald Steward, Mark Stopfer, F.G. Szele, Richard F. Thompson, Nicolas Toni, Bernard Truchet, Misha Tsodyks, K. Uryu, Ascher Uziel, Christopher S. Wallace, Yun Wang, Michael Wehr, Paul F. Worley, Xiaping Xie

Table of Contents

  1. Preface
  2. Introduction
  3. 1. Learning about Activity-Dependent Genes

    Dietmar Kuhl

  4. 2. Synaptic Regulation of Messenger RNA Trafficking within Neurons

    Oswald Steward, Christopher S. Wallace and Paul F. Worley

  5. 3. Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Neuronal Plasticity and Pathology

    Santiago Rivera and Michel Khrestchatisky

  6. 4. Long-Term Potentiation: From Molecular Mechanisms to Structural Changes

    Dominque Muller, Nicolas Toni and Pierre-Alain Buchs

  7. 5. Role of Synaptic Geometry in the Dynamics and Efficacy of Synaptic Transmission

    Jim-Shih Liaw, Xiaping Xie, Taraneh Ghaffari, Michel Baudry, Gilbert A. Chauvet and Theodore W. Berger

  8. 6. Neuron/Glia Signaling and Use-Dependent Modification of Synaptic Strength

    David J. Linden

  9. 7. Anatomical Plasticity in the Striatum during Development and after Lesions in the Adult Rat

    Marie-Françoise Chesselet, A. K. Butler, J. A. Napieralski, W. V. Morehouse, F. G. Szele and K. Uryu

  10. 8. Pathway-Specific Regulation of Synapses in the Thalamocortical System

    Barry W. Connors, Ziv Gil, Carole E. Landisman, Jay R. Gibson, and Yael Amitai

  11. 9. Dynamic Representation of Odors by Oscillating Neural Assemblies

    Gilles Laurent, Katrina MacLeod, Mark Stopfer, and Michael Wehr

  12. 10. Frequency-Dependent Synaptic Transmission in the Neocortex

    Henry Markram, Misha Tsodyks, Yun Wang, and Ascher Uziel

  13. 11. Neurobiological Substrates of Associative Memory: A Limbic-Cortical Dialogue

    François S. Roman, Franck A. Chaillan, Bruno Truchet, and Bernard Soumireu-Mourat

  14. 12. The Purkinje Local Circuit as an Example of a Functional Unit in the Nervous System

    Gilbert A. Chauvet and Pierre Chauvet

  15. 13. Synaptic Plasticity: From Molecules to Behavior

    Michel Baudry and Richard F. Thompson

  16. Contributors
  17. Index