ISBN: 9780262337854 | 424 pp. | December 2016

Computational Psychiatry

New Perspectives on Mental Illness
Modern psychiatry is at a crossroads, as it attempts to balance neurological analysis with psychological assessment. Computational neuroscience offers a new lens through which to view such thorny issues as diagnosis, treatment, and integration with neurobiology. In this volume, psychiatrists and theoretical and computational neuroscientists consider the potential of computational approaches to psychiatric issues.
This unique collaboration yields surprising results, innovative synergies, and novel open questions. The contributors consider mechanisms of psychiatric disorders, the use of computation and imaging to model psychiatric disorders, ways that computation can inform psychiatric nosology, and specific applications of the computational approach. 
Susanne E. Ahmari, Huda Akil, Deanna M. Barch, Matthew Botvinick, Michael Breakspear, Cameron S. Carter, Matthew V. Chafee, Sophie Denève, Daniel Durstewitz, Michael B. First, Shelly B. Flagel, Michael J. Frank, Karl J. Friston, Joshua A. Gordon, Katia M. Harlé, Crane Huang, Quentin J. M. Huys, Peter W. Kalivas, John H. Krystal, Zeb Kurth-Nelson, Angus W. MacDonald III, Tiago V. Maia, Robert C. Malenka, Sanjay J. Mathew, Christoph Mathys, P. Read Montague, Rosalyn Moran, Theoden I. Netoff, Yael Niv, John P. O’Doherty, Wolfgang M. Pauli, Martin P. Paulus, Frederike Petzschner, Daniel S. Pine, A. David Redish, Kerry Ressler, Katharina Schmack, Jordan W. Smoller, Klaas Enno Stephan, Anita Thapar, Heike Tost, Nelson Totah, Jennifer L. Zick

Table of Contents

  1. The Ernst Strüngmann Forum
  2. List of Contributors
  3. 1. On the Cusp

    Joshua A. Gordon and A. David Redish

  4. 2. Breakdowns and Failure Modes

    A. David Redish and Joshua A. Gordon

  5. 3. Complexity and Heterogeneityin Psychiatric Disorders

    Nelson Totah, Huda Akil, Quentin J. M. Huys, John H. Krystal, Angus W. MacDonald III, Tiago V. Maia, Robert C. Malenka, and Wolfgang M. Pauli

  6. 4. What Does Computational Psychiatry Need to Explain to Capture Mechanisms of Psychopathology?

    Deanna M. Barch

  7. 5. Computational Approaches for Studying Mechanisms of Psychiatric Disorders

    Zeb Kurth-Nelson, John p. O'Doherty, Deanna M. Barch, Sophie Denève, Daniel Durstewitz, Michael J. Frank, Joshua A. Gordon, Sanjay J. Matthew, Yael Niv, Kerry Ressler, and Heike Tost

  8. 6. Computational Cognitive Neuroscience Approaches to Deconstructing Mental Function and Dysfunction

    Michael J. Frank

  9. 7. How Could We Get Nosology from Computation?

    Christoph Mathys

  10. 8. Current State of Psychiatric Nosology

    Michael B. First

  11. 9. The Computation of Collapse

    Angus W. MacDonald III, Jennifer L. Zick, Theoden I. Netoff, and Matthew V. Chafee

  12. 10. A Novel Framework for Improving Psychiatric Diagnostic Nosology

    Shelly B. Flagel, Daniel S. Pine, Susanne E. Ahmari, Michael B. First, Karl J. Friston, Christoph Mathys, A. David Redish, Katharina Schmack, Jordan W. Smoller, and Anita Thapar

  13. 11. Computational Nosology and Precision Psychiatry

    Karl J. Friston

  14. 12. Candidate Examples for a Computational Approach to Address Practical Problems in Psychiatry

    Rosalyn Moran, Klaas Enno Stephan, Matthew Botvinick, Michael Breakspear, Cameron S. Carter, Peter W. Kalivas, P. Read Montague, Martin P. Paulus, and Frederike Petzchner

  15. 13. There Are No Killer Apps but Connecting Neural Activity to Behavior through Computation Is Still a Good Idea

    P. Read Montague

  16. 14. Call for Pragmatic Computational Psychiatry

    Martin P. Paulus, Crane Huang, and Katia M. Harlé

  17. 15. A Valuation Framework for Emotions Applied to Depression and Recurrence

    Quentin J. M. Huys

  18. 16. Clinical Heterogeneity Arising from Categorical and Dimensional Features of the Neurobiology of Psychiatric Diagnoses

    John H. Krystal, Alan Anticevic, John D. Murray, David Glahn, Naomi Driesen, Genevieve Yang, and Xiao-Jing Wang

  19. 17. From Psychiatry to Computation and Back Again

    A. David Redish and Joshua A. Gordon

  20. Bibliography
  21. Subject Index