Neural Transplantation

An Introduction

Although there are many scientific and philosophical reasons to study the brain, for William J. Freed, "the most compelling reason to study the brain is to be able to repair the brains of individuals with nervous system injury or disease." Advances in repairing the nervous system, as well as new data on brain development, growth, and plasticity, have revolutionized the field of brain research and given rise to the technology of brain tissue transplantation. In this book Freed discusses both what may and what may not be possible.

The book covers two aspects of neural tissue transplantation research. One involves the transplantation of particular cells to repair or augment specific neuronal systems. This technique could be useful for such conditions as Parkinson's disease, Huntington's disease, chronic pain, and epilepsy. The other line of research concerns regeneration from injury, especially of the spinal cord.

After providing basic background on transplantation, brain structure, and development, the book discusses Parkinson's disease, the use of transplants to influence localized brain functions, circuit reconstruction, and genetic engineering and other future technologies.

Table of Contents

  1. Preface
  2. Acknowledgments
  3. 1. Introduction to Transplantation in the Nervous System
  4. 2. Brain Structure and Development
  5. 3. History of Neural Transplantation
  6. 4. Transplants and How They Are Used
  7. 5. Control Groups and Experiments
  8. 6. Regulations and Guidelines for Fetal Tissue Transplantation
  9. 7. Mind Control and Other Things to Worry About
  10. 8. Neural Systems and Parkinson's Disease
  11. 9. Neural Transplantation in Parkinson's Disease: A Brief Synopsis
  12. 10. Fetal Brain Tissue Transplantation in Parkinson's Disease: Experiments in Animals
  13. 11. Adrenal Medulla Transplantation
  14. 12. Studies in Subhuman Primates
  15. 13. Fetal Brain Tissue Transplantation in Parkinson's Disease: Clinical Studies
  16. 14. Pain
  17. 15. Hypothalamus and Pituitary
  18. 16. The Cerebral Cortex and Stroke
  19. 17. Huntington's Disease
  20. 18. Spinal Cord
  21. 19. Visual System
  22. 20. Introduction to Genetic Engineering and Neural Transplantation
  23. 21. Growing Cells in Culture: Stem and Progenitor Cells
  24. 22. Growing Cells in Culture: Immortal Cell Lines
  25. 23. Genetically Modified Cells for Producing Neurotrophic Factors and Neurotransmitters
  26. 24. Direct Gene Transfer
  27. 25. Conclusions
  28. Glossary
  29. References
  30. Index