Regulators of Physiological Processes

In recent years there has been increasing interest and, subsequently, active research in neuropeptides. These neuroactive molecules coordinate, integrate, and regulate physiological processes in all organisms, throughout all phases of development. Acting as neurohormones, neurotransmitters, and/or neuromodulators, they maintain physiological homeostasis and influence important behavioral patterns. This textbook is the first to bring together and synthesize the neuropeptide research of the past decade in such a comprehensive, scholarly manner.

The book is divided into two parts. In Part I the author defines the basic principles of neuropeptide action, including their biosynthesis, processing, transport, distribution, and interactions with receptors and second messenger systems. Strand also discusses the intimate interaction between the neuropeptides, stress, and the immune system. In Part II she discusses the regulatory functions of the families of neuropeptide in sufficient detail to provide both the advanced student and senior investigator with a thorough understanding of the most important neuropeptides. The text also contains a complete and up-to-date reference/reading list.

Table of Contents

  1. Forward

    Charles F. Stevens

  2. Preface
  3. Acknowledgments
  4. I. General Characteristics of Neuropeptides
  5. 1. The Neuropeptide Concept and the Evolution of Neuropeptides
  6. 2. Methods of Studying Neuropeptides
  7. 3. Biosynthesis, Processing, Secretion, and inactivation of Neuropetides
  8. 4. Distribution and Localization of Neuropetides
  9. 5. The Neuroendocrine System and the Transport of Neuropeptides
  10. 6. Neuropeptide Receptors as Regulators of Cellular Functions
  11. 7. Neuropeptides as Neurotransmitters, Neuromodulators, and Neurohormones
  12. 8. Neuropeptides, Stress, and the Immune System
  13. II. Neuropeptide Familes: The Regulatory Role of Neuropeptides
  14. 9. Characteristics of Hypothalamic Regulatory Neuropeptides
  15. 10. Hypophysiotropic Neuropeptides: TRH, CRH, GnRH, GHRH, SS, PACAP, DSIP
  16. 11. Hypothalamic-Neurohypophyseal Hormones: VP and OT
  17. 12. Anterior Pituitary Neuropeptides I. The POMC-Derived Neuropeptides: ACTH, MSH, b-LPH, b-EP
  18. 13. Anterior Pituitary Neuropeptides II. The Glycoprotein and Growth Hormone Families; Secretoneurin
  19. 14. Endogenous Opiate Neuropeptides: Endorphins, Enkephalins, Dynorphins, Tyr-MIF-1, and Nociceptin
  20. 15. Tachykinins: Substance P, Neurokinin A, and Neurokinin B
  21. 16. Gut and Brain Neuropeptides I. Neuropeptide Families: Gastrin/CCK; VIP/Secretin/ Glucagon; PP/PYY/NPY; BN/GRP
  22. 17. Gut and Brain Neuropeptides II. Insulin, Galanin, Motilin, CGRP, Neurotensin
  23. 18. Cardiac, Renal, Parathyroid, and Thyroid Neuropeptides: ANH, AT, CT, PTH, PRH-rP, T3, T4
  24. 19. Invertebrate Neuropeptides
  25. References and Suggested Reading
  26. Appendix A: Abbreviations for Neuropeptides
  27. Appendix B: Miscellaneous Abbreviations
  28. Appendix C: Code Letters for Amino Acids
  29. Index