Evolution and Synthesis

Despite major advances in methodology and thousands of published studies every year, treatment outcomes in schizophrenia have not improved over the last fifty years. Moreover, we still lack strategies for prevention and we do not yet understand how the interaction of genetic, developmental, and environmental factors contribute to the disorder. In this book, leading researchers consider conceptual and technical obstacles to progress in understanding schizophrenia and suggest novel strategies for advancing research and treatment.

The contributors address a wide range of critical issues: the construct of schizophrenia itself; etiology, risk, prediction, and prevention; different methods of modeling the disorder; and treatment development and delivery. They identify crucial gaps in our knowledge and offer creative but feasible suggestions. These strategies include viewing schizophrenia as a heterogeneous group of conditions; adopting specific new approaches to prediction and early intervention; developing better integration of data across genetics, imaging, perception, cognition, phenomenology, and other fields; and moving toward an evidence-based, personalized approach to treatment requiring rational clinical decision-making to reduce functional disability.

Contributors: Robert Bittner, Robert W. Buchanan, Kristin S. Cadenhead, William T. Carpenter, Jr., Aiden Corvin, Daniel Durstewitz, André A. Fenton, Camilo de la Fuente-Sandoval, Jay A. Gingrich, Joshua A. Gordon, Chloe Gott, Peter B. Jones, René S. Kahn, Richard Keefe, Wolfgang Kelsch, James L. Kennedy, Matcheri S. Keshavan, Angus W. MacDonald III, Anil K. Malhotra, John McGrath, Andreas Meyer-Lindenberg, Kevin J. Mitchell, Bita Moghaddam, Vera A. Morgan, Craig Morgan, Kim T. Mueser, Karoly Nikolich, Patricio O'Donnell, Michael O'Donovan, William A. Phillips, Wulf Rössler, Louis Sass, Akira Sawa, Jeremy K. Seamans, Steven M. Silverstein, William Spaulding, Sharmili Sritharan, Heike Tost, Peter Uhlhaas, Aristotle Voineskos, Michèle Wessa, Leanne M. Williams, Ashley Wilson, Til Wykes

Table of Contents

  1. The Ernst Strüngmann Forum
  2. List of Contributors
  3. 1. Schizophrenia: The Nature of the Problems and the Need for Evolution and Synthesis in Our Approaches
  4. 2. What Kind of a Thing Is Schizophrenia? Specific Causation and General Failure Modes
  5. 3. How the Diagnosis of Schizophrenia Impeded the Advance of Knowledge (and What to Do About It)
  6. 4. What Dimensions of Heterogeneity Are Relevant for Treatment Outcome?
  7. 5. Which Aspects of Heterogeneity Are Useful to Translational Success?
  8. 6. How Should Resilience Factors Be Incorporated in Treatment Development?
  9. 7. Insights into New Treatments for Early Psychosis from Genetic, Neurodevelopment, and Cognitive Neuroscience Research
  10. 8. From Epidemiology to Mechanisms of Illness
  11. 9. How Can Risk and Resilience Factors Be Leveraged to Optimize Discovery Pathways?
  12. 10. Human Cell Models for Schizophrenia
  13. 11. How Can Animal Models Be Better Utilized?
  14. 12. How Can Computational Models Be Better Utilized for Understanding and Treating Schizophrenia?
  15. 13. How Can Models Be Better Utilized to Enhance Outcome? A Framework for Advancing the Use of Models in Schizophrenia
  16. 14. Why Kraepelin Was Right: Schizophrenia as a Cognitive Disorder
  17. 15. What Will the Next Generation of Psychosocial Treatments Look Like?
  18. 16. Creative Solutions to Overcoming Barriers in Treatment Utilization: An International Perspective
  19. 17. What Is Necessary to Enhance Development and Utilization of Treatment?
  20. Bibliography
  21. Subject Index