Monthly
208 pp. per issue
8 1/2 x 11, illustrated
ISSN
0898-929X
E-ISSN
1530-8898
2014 Impact factor:
4.69

Journal of Cognitive Neuroscience

March 2005, Vol. 17, No. 3, Pages 446-462
(doi: 10.1162/0898929053279496)
© 2005 Massachusetts Institute of Technology
“Where to?” Remote Memory for Spatial Relations and Landmark Identity in Former Taxi Drivers with Alzheimer's Disease and Encephalitis
Article PDF (4.29 MB)
Abstract

Recent research suggests that the hippocampus is not needed for the maintenance and recovery of extensively used environments learned long ago. Instead, a network of neo-cortical regions differentially supports memory for location-navigation knowledge and visual appearance of well-known places. In this study, we present a patient, S. B., who was diagnosed with probable Alzheimer's disease long after retiring from his 40 years as a taxi driver in downtown Toronto, a place that he has visited rarely, if ever, in the last decade. His performance was compared to that of two other retired taxi drivers, L. R., who developed encephalitis after retirement, and I. L., who is without neurological illness, and a group of eight healthy control participants who were never taxi drivers but all of whom worked or lived in downtown Toronto until at least 10 years ago. Despite S. B.'s widespread atrophy, which has affected mainly his hippocampus and part of his occipitotemporal cortex, he performed at least as well as all other participants on remote memory tests of spatial location and mental navigation between well-known Toronto landmarks. Unlike the comparison populations, however, he was unable to discriminate between the appearances of landmarks that he had visited frequently in his many years as a taxi driver from unknown buildings. This profound deficit extended to famous world landmarks but not to famous faces and does not appear to be semantic in nature. These findings add further support to the claim that the hippocampus is not necessary for mental navigation of old environments and suggest that expertise is not sufficient to protect against landmark agnosia.