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6 x 9, illustrated
ISSN
0899-7667
E-ISSN
1530-888X
2014 Impact factor:
2.21

Neural Computation

July 2011, Vol. 23, No. 7, Pages 1675-1703
(doi: 10.1162/NECO_a_00139)
© 2011 Massachusetts Institute of Technology
Spiking Neurons and the First Passage Problem
Article PDF (565.93 KB)
Abstract

We derive a model of a neuron’s interspike interval probability density through analysis of the first passage problem. The fit of our expression to retinal ganglion cell laboratory data extracts three physiologically relevant parameters, with which our model yields input-output features that conform to laboratory results. Preliminary analysis suggests that under common circumstances, local circuitry readjusts these parameters with changes in firing rate and so endeavors to faithfully replicate an input signal. Further results suggest that the so-called principle of sloppy workmanship also plays a role in evolution’s choice of these parameters.