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ISSN
1064-5462
E-ISSN
1530-9185
2014 Impact factor:
1.39

Artificial Life

Spring 2012, Vol. 18, No. 2, Pages 223-236
(doi: 10.1162/artl_a_00060)
© 2012 Massachusetts Institute of Technology
A Simple Computational Cell: Coupling Boolean Gene and Protein Networks
Article PDF (894.24 KB)
Abstract

This article presents an abstract, tunable model containing two of the principal information-processing features of cells and explores its use with simulated evolution. The random Boolean model of genetic regulatory networks is extended to include a protein interaction network. The underlying behavior of the resulting two coupled dynamical networks is investigated before their evolvability is explored using a version of the NK model of fitness landscapes.