Monthly
208 pp. per issue
8 1/2 x 11, illustrated
ISSN
0898-929X
E-ISSN
1530-8898
2014 Impact factor:
4.69

Journal of Cognitive Neuroscience

Fall 1989, Vol. 1, No. 4, Pages 327-335.
(doi: 10.1162/jocn.1989.1.4.327)
© 1989 by the Massachusetts Institute of Technology
Does Scopolamine Directly Impair Memory?
Article PDF (1.06 MB)
Abstract

Enhanced cued recall, a procedure which circumvents inattention and induces semantic processing, was used to determine if scopolamine produces direct impairment of specific memory mechanisms or indirect impairment of memory secondary to impairment of other cognitive processes. In two studies, cognitively normal young adults given moderate or high doses of scopolamine maintained maximum cued recall in spite of a dose-dependent decrement in free recall. This finding suggests that cholinergic blockade may impair memory indirectly through effects on other cognitive processes.