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Journal of Cognitive Neuroscience

Summer 1993, Vol. 5, No. 3, Pages 303-316
(doi: 10.1162/jocn.1993.5.3.303)
© 1993 by the Massachusetts Institute of Technology
Express Saccades and Smooth Pursuit Eye Movement Function in Schizophrenic, Affective Disorder, and Normal Subjects
Article PDF (1.42 MB)

Saccadic and smooth pursuit eye movements were recorded in three groups of subjects: a schizophrenic group, a non-schizophrenic psychotic patient comparison group, and a normal control group. Schizophrenic subjects demonstrated a greater decrease in saccadic response time than did normal controls in a gap task (when the fixation point was turned off 150 msec before the target appeared). The psychiatric comparison subjects did not differ from normal controls. Further, only schizophrenic subjects demonstrated a relation between smooth pursuit and saccadic eye movement performance, such that subjects with impaired smooth pursuit showed a larger decrease in saccadic response time in the gap task. The relation between performance on the gap task and quality of smooth pursuit and its relevance for a prefrontal deficit hypothesis of schizophrenia are discussed.