Monthly
208 pp. per issue
8 1/2 x 11, illustrated
ISSN
0898-929X
E-ISSN
1530-8898
2014 Impact factor:
4.69

Journal of Cognitive Neuroscience

September 2014, Vol. 26, No. 9, Pages 2102-2110
(doi: 10.1162/jocn_a_00622)
@ 2014 Massachusetts Institute of Technology
The Face of Negative Affect: Trial-by-Trial Corrugator Responses to Negative Pictures Are Positively Associated with Amygdala and Negatively Associated with Ventromedial Prefrontal Cortex Activity
Article PDF (354.44 KB)
Abstract

The ability to simultaneously acquire objective physiological measures of emotion concurrent with fMRI holds the promise to enhance our understanding of the biological bases of affect and thus improve our knowledge of the neural circuitry underlying psychiatric disorders. However, the vast majority of neuroimaging studies to date examining emotion have not anchored the examination of emotion-responding circuitry to objective measures of emotional processing. To that end, we acquired EMG activity of a valence-sensitive facial muscle involved in the frowning response (corrugator muscle) concurrent with fMRI while twenty-six human participants viewed negative and neutral images. Trial-by-trial increases in corrugator EMG activity to negative pictures were associated with greater amygdala activity and a concurrent decrease in ventromedial PFC activity. Thus, this study highlights the reciprocal relation between amygdalar and ventromedial PFC in the encoding of emotional valence as reflected by facial expression.