288 pp. per issue
6 x 9, illustrated
2014 Impact factor:

Neural Computation

February 2007, Vol. 19, No. 2, Pages 327-350
(doi: 10.1162/neco.2007.19.2.327)
© 2007 Massachusetts Institute of Technology
Thermodynamically Equivalent Silicon Models of Voltage-Dependent Ion Channels
Article PDF (327.51 KB)

We model ion channels in silicon by exploiting similarities between the thermodynamic principles that govern ion channels and those that govern transistors. Using just eight transistors, we replicate—for the first time in silicon—the sigmoidal voltage dependence of activation (or inactivation) and the bell-shaped voltage-dependence of its time constant. We derive equations describing the dynamics of our silicon analog and explore its flexibility by varying various parameters. In addition, we validate the design by implementing a channel with a single activation variable. The design's compactness allows tens of thousands of copies to be built on a single chip, facilitating the study of biologically realistic models of neural computation at the network level in silicon.