288 pp. per issue
6 x 9, illustrated
2014 Impact factor:

Neural Computation

October 2008, Vol. 20, No. 10, Pages 2491-2525
(doi: 10.1162/neco.2008.03-07-498)
© 2008 Massachusetts Institute of Technology
Understanding Parkinsonian Handwriting Through a Computational Model of Basal Ganglia
Article PDF (5.79 MB)

Handwriting in Parkinson's disease (PD) is typically characterized by micrographia, jagged line contour, and unusual fluctuations in pen tip velocity. Although PD handwriting features have been used for diagnostics, they are not based on a signaling model of basal ganglia (BG). In this letter, we present a computational model of handwriting generation that highlights the role of BG. When PD conditions like reduced dopamine and altered dynamics of the subthalamic nucleus and globus pallidus externa subsystems are simulated, the handwriting produced by the model manifested characteristic PD handwriting distortions like micrographia and velocity fluctuations. Our approach to PD modeling is in tune with the perspective that PD is a dynamic disease.