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Dec 1999
ISBN 0262062089
459 pp.
70 illus.
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Neural Transplantation
William J. Freed

"This book is engaging and insightful, and has little gems of information throughout. It will prove accessible for a large educated audience, yet will also hold the interest of experts in the field. I highly recommend it."
-- Jill B. Becker, Professor of Psychology, The University of Michigan, Ann Arbor

Although there are many scientific and philosophical reasons to study the brain, for William J. Freed, "the most compelling reason to study the brain is to be able to repair the brains of individuals with nervous system injury or disease." Advances in repairing the nervous system, as well as new data on brain development, growth, and plasticity, have revolutionized the field of brain research and given rise to the technology of brain tissue transplantation. In this book Freed discusses both what may and what may not be possible.

The book covers two aspects of neural tissue transplantation research. One involves the transplantation of particular cells to repair or augment specific neuronal systems. This technique could be useful for such conditions as Parkinson's disease, Huntington's disease, chronic pain, and epilepsy. The other line of research concerns regeneration from injury, especially of the spinal cord.

After providing basic background on transplantation, brain structure, and development, the book discusses Parkinson's disease, the use of transplants to influence localized brain functions, circuit reconstruction, and genetic engineering and other future technologies.

Table of Contents
 PREFACE
 ACKNOWLEDGMENTS
1 Introduction to Transplantation in the Nervous System
2 Brain Structure and Development
3 History of Neural Transplantation
4 Transplants and How They Are Used
5 Control Groups and Experiments
6 Regulations and Guidelines for Fetal Tissue Transplantation
7 Mind Control and Other Things to Worry About
8   Neural Systems and Parkinson's Disease
9 Neural Transplantation in Parkinson's Disease: A Brief Synopsis
10 Fetal Brain Tissue Transplantation in Parkinson's Disease: Experiments in Animals
11 Adrenal Medulla Transplantation
12 Studies in Subhuman Primates
13 Fetal Brain Tissue Transplantation in Parkinson's Disease: Clinical Studies
14 Pain
15 Hypothalamus and Pituitary
16 The Cerebral Cortex and Stroke
17 Huntington's Disease
18 Spinal Cord
19 Visual System
20 Introduction to Genetic Engineering and Neural Transplantation
21 Growing Cells in Culture: Stem and Progenitor Cells
22 Growing Cells in Culture: Immortal Cell Lines
23 Genetically Modified Cells for Producing Neurotrophic Factors and Neurotransmitters
24 Direct Gene Transfer
25 Conclusions
 GLOSSARY
 REFERENCES
 INDEX
 
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