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Abstract:
The initial activity-independent formation of a topographic
map in the retinotectal system has long been thought to rely on the
matching of molecular cues expressed in gradients in the retina and
the tectum. However, direct experimental evidence for the existence
of such gradients has only emerged in the past two years. The new
data has provoked the discussion of a new set of models in the
experimental literature. Here, these models are subjected to a
rigourous theoretical analysis.
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