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Estrogen and Memory Performance in Post-Menopausal Women.

 Barbara J. Cherry, Gretchen B. Scott, Scott T. Grafton, Joseph B. Hellige and Victor W. Henderson
  
 

Abstract:
Thirty-one post-menopausal women (15 users, 16 non-users of estrogen) named pictures presented on computer and performed a pursuit rotor task. Estrogen users vs. non-users were not different in terms of age, education, depression, or scores on the Mini-Mental State Examination. Embedded in the naming task were three priming conditions: identity (e.g., bear-bear), related (e.g., apple-orange) and unrelated (e.g., hammer-vest). Voice-activated reaction time (RT) to correctly-named pictures were significantly different for the three conditions, with shortest RTs for identity primes and longest RTs for unrelated primes. Using a difference score for unrelated minus identity RTs, estrogen users showed a trend towards increased priming compared to non-users, p = .09. Estrogen users vs. non-users were not significantly different on overall naming performance for either RT or accuracy. For the pursuit rotor task, twenty-eight women (13 users, 15 non-users of estrogen) showed comparable learning and memory, with percentage time on target (per 20 s trials) increasing over four blocks of trials by 21 percent and maintaining for 2 blocks of trials after a 30 minute delay. Results fail to confirm a (substantial) advantage for estrogen use after the menopause on picture naming and pursuit rotor tasks.

 
 


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