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Abstract:
Memory is a process involving mechanisms at both cellular and
systems levels. I will be describing our efforts to study the
changes in neuronal activity that occur within the rodent
hippocampus following experience by combining molecular,
behavioral, and electrophysiological approaches. By comparing
changes that occur during novel experience to those that follow
molecular disruptions of plasticity we can begin to identify the
basic characteristics of neuronal activity that may be critical to
rapid memory formation. I will also describe recent work examining
the interactions between the hippocampus and neocortex and memory
related activity within the hippocampus that might relate to
mechanisms of longer-term memory consolidation during sleep.
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