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A Case-Control Study of Heritability of Language, Reading, and Auditory Rate Processing Disorders.

 Paula Tallal, Judy Flax, Linda S. Hirsch and Teresa Realpe
  
 

Abstract:
Recent research indicates a strong genetic component for both language and reading skills. Longitudinal studies have demonstrated that children with early language impairment are at risk for later reading problems. Other studies have shown a high correlation between the rate of processing rapidly successive sensory information and phonological awareness important in both oral and written language development. Based on these facts, one might expect all three areas (rapid processing, language, and reading) to share a common inheritance. The current study investigates the incidence of language, reading, and rate processing difficulties in families with and without a child identified with specific language impairment (SLI). The families of twenty five SLIs (probands) and 22 controls received a battery of neuropsychological tests, including language, reading, and a test of auditory processing rate. In the proband families there were significantly more siblings and parents identified as SLI (28% vs. 5.5%, p<.001). Of those subjects identified as SLI, 25.5% also demonstrated deficits in reading and auditory processing rates. Less than 3% of non-SLIs demonstrated deficits in these areas lending support to the notion that language, reading, and rate processing difficulties co-exist and that family history can play a significant role in the transmission of these problems. Gene linkage studies are currently underway.

 
 


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