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Abstract:
Abstract: Previous studies of children with early lesions and
patients with adult-onset lesions have demonstrated spatial
analytic deficits following posterior brain injury. The current
study examined neuroanatomic cerebral brain development in children
with anterior parietal and frontal injury to determine whether
atypical development was evident in intact posterior regions
following early injury. Additionally, childrenUs performance on
visual spatial tasks was examined for corresponding behavioral
profiles. MRI-based quantitative image analysis was used to measure
occipital lobe gray and white matter volumes in four children with
pre and perinatal unilateral lesions. Behavioral measures of
spatial analysis included three tasks of block construction and
drawing. Volumetric measures revealed a reduction in white matter
volume in the intact occipital lobes. Spatial deficits accompanied
the remote white matter loss. The deficits observed resembled those
seen in children and adults with direct injury to posterior brain
regions.
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