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Abstract:
Abstract: To reveal how monkey's prefrontal cortex (PFC) uses
visual, motor, and reward information to flexibly control
behaviors, we recorded single cell activity from the PFC of 2
monkeys, while they were performing a visually cued GO/NO-GO task
with motor and reward reversals. While the monkey was gazing a
fixation point (FP), one of two visual cues was presented for 0.6
s. When the FP dimmed after a delay, the monkey was required to
conduct GO or NO-GO motor responses depending on the cue. The
reward was asymmetrically given after correct GO or correct NO-GO
responses. By recording activity of single cells across motor and
reward reversals, we measured the contribution of visual, motor and
reward factors to the activity. Seventy-four cells, which were
recorded from the lateral surface above and below the principal
sulcus, showed differential activity during the cue and/or delay
periods. Three-way or two-way ANOVA showed that reward main effects
were significant in 50% cells in both cue and delay periods. Visual
main effects decreased from the cue to delay period (43% to 20%),
while motor main effects increased (16% to 47%). Thus, in the
lateral prefrontal cortex, the initial representation of visual cue
was replaced by that of required motor response during the delay
period while the information of anticipated reward was
maintained.
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