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Neural Correlates of Response Inhibition and Working Memory

 Elysia Poggi Davis, Jacqueline Bruce, Kelly Snyder and Charles A. Nelson
  
 

Abstract:
Abstract: Event-related potentials were recorded from 6-year old children and adults during two tasks designed to assess response inhibition. The first task, a "Go-NOGO" task, requires the subject to selectively attend and respond to non-target stimuli while inhibiting their response to an equally salient target stimulus. The second task is a working memory task, which also contains a response inhibition condition. In this task, subjects must inhibit a response to a "non-target" that was primed by the previous "target" trial. ERPs were recorded from sixteen scalp sites. The accuracy (i.e. percent correct) and speed (i.e. average reaction time) of responding to the control and response inhibition trials will be compared across children and adults, and correlated with the elicited ERP components, for each task. It is predicted that the amplitude of the P300 (related to memory updating) and N200 (related to attention) will be greater for inhibitory trials than control trials, and that these components will be maximal over frontal leads for the inhibitory trials. In addition, it is expected that larger P300s and N200s will be related to greater accuracy and that the latency to peak amplitude of these components will be correlated with reaction time.

 
 


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