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Abstract:
Abstract: Here we describe a new method, using SPM99, that
searches explicitly for bilateral structural abnormalities.
Children with bilateral pathology have a poorer prognosis than
children with unilateral brain abnormalities. After brain injury or
disease in childhood, it is thought that rescue of function is only
possible if the neuronal substrates of that function are preserved
and operational in at least one hemisphere [Vargha-Khadem and
Mishkin 1997, In Pediatric epilepsy syndromes and their surgical
treatment Eds: Tuxhom,I; Holthainsen,H; Boenigl,H.E.]. If this is
the case, the detection of bilateral abnormalities would greatly
facilitate more accurate prognosis in children with developmental
disorders or with brain injury. We have therefore developed a
technique to detect bilateral abnormalities that uses conjunction
analysis with voxel based morphometry. This method is illustrated
using a group of patients with bilateral hypoxic-ischaemic damage
to the hippocampus. The approach is shown to have enhanced
specificity and sensitivity relative to conventional unilateral
characterisations.
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