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Midazolam-induced Amnesia and the Process Dissociation Procedure

 Miriam Z. Mintzer, Roland R. Griffiths and Elliot Hirshman
  
 

Abstract:
Abstract: The purpose of the present study was to use midazolam-induced amnesia to explore the plausibility of the estimates provided by the process dissociation procedure (PDP; Jacoby et al., 1993), which is designed to estimate the contributions of conscious (C) and unconscious (U) processes to implicit memory performance. In a double-blind, placebo-controlled, within-subject design with 24 participants, single midazolam doses were administered intravenously, and word stem completion performance was used to calculate PDP estimates. Midazolam administration produced a dissociation between effects on estimates of C vs. U, such that midazolam decreased C but increased U relative to placebo. Given that a manipulation which induces amnesia would not be expected to increase memory performance, these results add to the accumulating body of evidence suggesting that PDP estimates are not always theoretically plausible. The finding that this dissociation occurred following semantic but not orthographic encoding provides particularly compelling evidence against the viability of the PDP, given that the within-subject manipulation of encoding forces interpretation of participants' strategy to be equated across encoding condition, and that interpretation of participants' strategy plays a critical role for Jacoby and colleagues in generating predictions regarding the expected pattern of PDP estimates. Redundancy may be a more plausible model of the underlying relationship between C and U than the PDP's independence model.

 
 


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