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Abstract:
Abstract: Many influential claims about the organization of
working memory function in prefrontal cortex have been developed
and/or tested with functional neuroimaging methods featuring the
blocking of behavioral trials and the averaging across blocks of
neuroimaging signal. Interpretation of the results of these first
generation neuroimaging studies is subject to several inferential
constraints, which thereby weaken the models derived from them. We
reassessed several models of the functional organization of working
memory in prefrontal cortex by examining or reanalyzing data from
three event-related fMRI studies of working memory function
performed in our laboratory (D'Esposito et al., 1999; Postle et
al., 1999; Postle & D'Esposito, 1999), data that were not
subject to the same inferential constraints. This process permitted
us to reject some of the models derived from first generation
neuroimaging data, to refine others, and to synthesize our results
into a revised hybrid model of the working memory functions of
prefrontal cortex.
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