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Abstract:
Abstract: Results derived from diverse methods such as fMRI,
cognitive testing, animal models, pharmacological manipulations,
and the study of clinical populations will be discussed as they
bear on the development of working memory and inhibitory control
functions dependent on dorsolateral prefrontal cortex (DL-PFC).
Examples of results to be discussed include: (1) Our findings
indicate that while there are marked developmental improvements
from 4 years to adulthood in the inhibitory control ability
dependent on DL-PFC, little improvement is seen over the same
period in the working memory ability dependent on DL-PFC. (2) While
neuroimaging and lesion studies in humans and animals demonstrate
that DL-PFC is critical for success on the delayed response and
self-ordered pointing tasks, work with children with a selective
depletion of dopamine in DL-PFC and with an animal model
demonstrates that while reducing dopamine in DL-PFC impairs
performance on delayed response it does not impair self-ordered
pointing.
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