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Abstract:
Prior research has identified neural correlates of successful
retrieval of episodic information from memory, including left
anterior prefrontal, premotor, and lateral and medial parietal
cortex. These studies have often used verbal (word) stimuli, which
raises the question of whether activation of this network is
specific to retrieval of verbal information. Subjects studied two
different sets of pictures and sounds, each paired with a
descriptive label. One set was studied one time (PIC1, SND1) and
the other twenty times (PIC20, SND20). We later scanned subjects
while they performed a source recognition task in which they saw
OLD and NEW words and made a response to indicate OLD and studied
with a picture, OLD and studied with a sound, or NEW. Comparison of
retrieved pictures and sounds (Hits) versus correct identification
of NEW words (Correct Rejections) showed increased activation of
bilateral anterior frontal and lateral and medial parietal cortex
for PIC1, PIC20, and SND20 conditions. SND1 resulted in increased
activation in left parietal cortex. These results suggest that the
previously identified retrieval success network is recruited during
retrieval in general, and is not limited to verbal processing.
These results are discussed in the context of additional
modality-specific regions that are recruited differentially during
access to sound and picture information.
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