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Temporal Correlations in Fmri Data Reflect Functional Connectivity Between Language Regions

 Michelle Hampson, Bradley S. Peterson, Pawel Skudlarski, James C. Gatenby and John C. Gore
  
 

Abstract:
Functional magnetic resonance imaging (fMRI) was used to investigate low frequency temporal correlations in blood oxygenation level between Broca's area and Wernicke's area. These brain regions, which have long been implicated in language processing, are nonadjacent, nonhomologous, and known to be strongly neurally connected. The signals from Broca's area and Wernicke's area were found to be correlated during resting state scans and this correlation was found to increase when subjects listened to continuous speech. These findings are consistent with the hypothesis that low-frequency resting state correlations in BOLD (Blood Oxygenation Level Dependent) signals can reveal functional connections in high-level cognitive systems. In addition, they support the possibility that the degrees of interactions between brain regions are reflected by the magnitudes of such correlations.

 
 


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