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Abstract:
We present a model of the firing of place and head-direction
cells in rat hippocampus. The model can predict the response of
individual cells and populations to parametric manipulations of
both geometric (e.g. O'Keefe and Burgess, 1996) and orientational
(Fenton et al., 2000a) cues, extending a previous geometric model
(Hartley et al., 2000). It provides a functional description of
how these cells' spatial responses are derived from the rat's
environment and makes easily testable quantitative predictions.
Consideration of the phenomenon of remapping (Muller and Kubie,
1987; Bostock et al., 1991) indicates that the model may also be
consistent with nonparametric changes in firing, and provides
constraints for its future development.
References
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Experience-dependent modifications of hippocampal place cell
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Fenton, A. A., G. Csizmadia, and R. U. Muller (2000a).
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Nature
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