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Retinal organization is deceptively simple; its simplicity and beauty have drawn many a researcher's attention. The relationship between structure and function has been explored since the time of the elegant work of Ramón y Cajal. Although over 100 years of study has unraveled many secrets, a complete understanding of retinal function eludes us.
Nevertheless, the basic principles of retinal organization and development are understood in greater detail than those of any other region of the central nervous system. The basic anatomy and physiology of the retina were discussed in the foregoing chapters of this edition (see chapters 6, 7, and 8; see also the Selected Readings). Two questions are the subject of this review:
1. What is the ultrastructural organization of the synaptic layers in the retina?
2. How do cell adhesion and extracellular matrix molecules contribute to the development of connectivity in the retina?
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