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Wasterlain: Reference

April 2006
ISBN 0-262-23245-6
8.5 x 11, 649 pp., 196 illus.
12-page color insert
$135.00/£87.95 (CLOTH)

Status Epilepticus, Mechanisms and Management
Edited by Claude G. Wasterlain and David M. Treiman

Interest in status epilepticus--the most extreme form of epilepsy, involving continuous seizures--has surged in the last 20 years. The book focuses on the two areas in which progress has been most rapid: basic mechanisms and treatment. After an overview of history, classification, and epidemiology, the contributors consider clinical phenomenology, biological markers, pathophysiology, brain damage, epileptogenesis, therapeutic principles, pharmacology, and therapeutic management.

Claude G. Wasterlain is Chief of the Department of Neurology at the West Los Angeles VA Medical Center and Distinguished Professor and Vice Chair of the Department of Neurology at UCLA.

David M. Treiman is Director of the Epilepsy Center at the Barrow Neurological Institute at St. Joseph's Hospital and Medical Center, Phoenix.

Table of Contents

	Abstract
	Preface
I.	STATUS EPILEPTICUS: HISTORY, DEFINITION, CLASSIFICATION, AND EPIDEMIOLOGY
	1.	Historical Overview Brian S. Meldrum
	2.	Definition and Classification of Status Epilepticus Claude G. Wasterlain and James W. Chen
	3.	Incidence and Causes of Status Epilepticus Robert J. DeLorenzo
	4.	Prognosis after a First Episode of Status Epilepticus Giancarlo Logroscino, Dale C. Hesdorffer, and W. Allen Hauser
	5.	Epidemiology of Childhood Status Epilepticus Shlomo Shinnar
II.	STATUS EPILEPTICUS: CLINICAL PHENOMENOLOGY
	6.	Generalized Convulsive Status Epilepticus David M. Treiman
	7.	Simple and Complex Partial Status Epilepticus Pierre Thomas, Benjamin Zifkin, and Frederick Andermann
	8.	Absence Status Pierre Thomas, Benjamin Zifkin, and Frederick Andermann
	9.	The Two Faces of Electrographic Status Epilepticus: The Walking Wounded and the Ictally Comatose Denson G. Fujikawa
	10.	Status Epilepticus in Infancy and Childhood Joyce Y. Wu, Susan Koh, and Raman Sankar
	11.	Nonconvulsive Status Epilepticus in Children: With Special Reference to Electrical Status Epilepticus During Slow-Wave Sleep Syndrome (ESES Syndrome) Shunsuke Ohtahara, Yasuko Yamatogi, Katsuhiro Kobayashi, and Naohiro Nishibayashi
	12.	Status Epilepticus in the Neonate Eli M. Mizrahi
III.	STATUS EPILEPTICUS: BIOLOGICAL MARKERS
	13.	Physiologic Responses to Status Epilepticus Roger P. Simon
	14.	Clinical Neuropathology in Convulsive Status Epilepticus Heinz-Joachim Meencke and Gerhard Veith
	15.	Neuron-Specific Enolase in Status Epilepticus Christopher M. DeGiorgio, Adrian L. Rabinowicz, Jorge Correale, Christi Norton Heck, Peggy S. Gott, and Steven Schreiber
	16.	Brain Imaging in Status Epilepticus Thomas R. Henry
IV.	BASIC MECHANISMS: PATHOPHYSIOLOGY
	17.	Self-Sustaining Status Epilepticus Andrey M. Mazarati, Hantao Liu, David E. Naylor, Lucie Suchomelová, Kerry W. Thompson, Anne Pereira de Vasconselos, Raman Sankar, Astrid Nehlig, and Claude G. Wasterlain
	18.	Pathophysiology of Seizure Circuitry in Status Epilepticus Dan C. McIntyre, Mary Ellen Kelly, and William A. Staines
	19.	Neuroanatomy of Status Epilepticus Adrian Handforth
	20.	Role of GABAA Receptors in Status Epilepticus Robert L. Macdonald and Jaideep Kapur
	21.	Physiologic Mechanisms of Inhibition and Status Epilepticus Igor Spigelman
	22.	Glutamate and Glutamate Receptors in Status Epilepticus Astrid G. Chapman and Brian S. Meldrum
	23.	Metabotropic Receptors in Status Epilepticus Brian S. Meldrum
	24.	The Role of Adenosine in Status Epilepticus Deborah Young and Michael Dragunow
V.	BASIC MECHANISMS: BRAIN DAMAGE
	25.	Excitotoxicity in Status Epilepticus Luiz E. A. M. Mello, Luciene Covolan, Clement Hamani, and Ricardo Luis Smith
	26.	Seizure-Induced Damage in the Immature Brain: Overcoming the Burden of Proof Kerry W. Thompson and Raman Sankar
	27.	Metabolic and Circulatory Adaptations to Status Epilepticus in the Immature Brain Astrid Nehlig and Anne Pereira de Vasconcelos
	28.	Excitotoxicity and Seizures in the Immature Brain Pavel Mareš
	29.	Age-Specific Mechanisms of Status Epilepticus Jana Velíšková, Rina Wu, and Solomon L. Moshé
	30.	Developmental Differences in Seizure Susceptibility and Hippocampal Vulnerability: Molecular Correlates Linda K. Friedman and Ellen F. Sperber
	31.	Seizures and Neurotrophic Factor Expression Harley I. Kornblum and Christine M. Gall
	32.	Behavioral Consequences of Status Epilepticus in the Immature Brain Gregory L. Holmes, Roustem Khazipov, Zhao Liu, Matthew R. Sarkisian, and Carl E. Stafstrom
VI.	BASIC MECHANISMS: EPILEPTOGENESIS
	33.	Late Consequences of Status Epilepticus João Pereira Leite, Alexandre Valotta da Silva, and Esper A. Cavalheiro
	34.	Epileptogenic Effects of Status Epilepticus Yukiyoshi Shirasaka, Lucie Suchomelová, Andrey M. Mazarati, and Claude G. Wasterlain
	35.	Hippocampal Reactive Synaptogenesis from Status Epilepticus Gary W. Mathern
VII.	THERAPEUTIC PRINCIPLES
	36.	Neuroprotective Strategies in Status Epilepticus Denson G. Fujikawa
	37.	Generalized Convulsive Status Epilepticus: Principles of Treatment Edward Faught and Christopher M. DeGiorgio
	38.	Therapeutic Attitudes and Therapeutic Algorithms Claude G. Wasterlain
	39.	Approach to the Management of Neonatal Status Epilepticus Hoda Z. Abdel-Hamid and Michael J. Painter
	40.	Management of Status Epilepticus in Infants and Children Philippe Evrard, Alexis Arzimanoglou, Isabelle Husson, Pierre Gressens, and Raman Sankar
VIII.	PHARMACOTHERAPY
	41.	Benzodiazepines for Initial Treatment of Status Epilepticus Brian K. Alldredge
	42.	Phenytoin in the Treatment of Status Epilepticus Ilo E. Leppik
	43.	Phenytoin and Fosphenytoin R. Eugene Ramsay and Flavia M. Pryor
	44.	Phenobarbital in the Treatment of Status Epilepticus Edward Faught
	45.	Valproate Sunita Dergalust, Roi Ann Wallis, and Kimberly L. Panizzon
	46.	Other Pharmacologic Therapy for Refractory Status Epilepticus Alan G. Stein and Robert S. Fisher
IX.	THERAPEUTIC MANAGEMENT
	47.	Approaches to Treating Status Epilepticus Outside the Hospital John W. Miller and Gail D. Anderson
	48.	The Treatment of Status Epilepticus Patients in the Emergency Setting Edward P. Sloan
	49.	Critical Care of the Status Epilepticus Patient Thomas P. Bleck
	50.	The Impact of Status Epilepticus on Health Care Delivery Systems: Quality of Care and Access Barbara G. Vickrey
	51.	Status Epilepticus: The Future Claude G. Wasterlain and David M. Treiman
	Contributors
	Index