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ISSN
0898-929X
E-ISSN
1530-8898
2014 Impact factor:
4.69

Journal of Cognitive Neuroscience

April 1, 2003, Vol. 15, No. 3, Pages 409-418
(doi: 10.1162/089892903321593126)
© 2003 Massachusetts Institute of Technology
Success and Failure Suppressing Reflexive Behavior
Article PDF (1.41 MB)
Abstract

The dynamic interplay between reflexive and controlled determinants of behavior is one of the most general organizing principles of brain function. A powerful analogue of this interplay is seen in the antisaccade task, which pits reflexive and willed saccadic mechanisms against one another. Event-related functional magnetic resonance imaging of the human brain showed greater prestimulus preparatory activity in the pre-supplementary motor area before voluntary antisaccades (saccades away from a target) compared with reflexive prosaccades (saccades to a target). Moreover, this preparatory activity was critically associated with reflex suppression; it predicted whether the reflex was later successfully inhibited in the trial. These data illustrate a mechanism for top-down control over reflexive behavior.